Inhibitory and Enzyme-Kinetic Investigation of Chelerythrine and Lupeol Isolated fromZanthoxylum rhoifoliumAgainst Krait Snake Venom Acetylcholinesterase
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چکیده
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Enzymatic and biochemical characterization of Bungarus sindanus snake venom acetylcholinesterase
This study analyses venom from the elapid krait snake Bungarus sindanus, which contains a high level of acetylcholinesterase (AChE) activity. The enzyme showed optimum activity at alkaline pH (8.5) and 45°C. Krait venom AChE was inhibited by substrate. Inhibition was significantly reduced by using a high ionic strength buffer; low ionic strength buffer (10 mM PO4 pH 7.5) inhibited the enzyme by...
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Many active secretions produced by animals have been employed in the development of new drugs to treat diseases such as hypertension and cancer. Snake venom toxins contributed significantly to the treatment of many medical conditions. Venomous snakes have a bad reputation and rightly so because of their often deadly bites. But what makes a snake’s bite so deadly is the venom. Of the 3000 snake ...
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چکیده ندارد.
In vitro kinetics and inhibition of krait snake’s venom acetylcholinesterase by Calligonum polygonoides extract in relation to the treatment of Alzheimer’s disease
Objective(s): The objective of this study was to evaluate pharmacological effect of Calligonum polygonoides against Krait snake’s venom acetylcholinesterase (AChE) and to extent it for the treatment of Alzheimer’s disease. Materials and Methods: Acetylcholinesterase activity was measured using Ellman method with some modification. The kinetic studies of methanolic extract of C. polygonoides aga...
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ژورنال
عنوان ژورنال: Journal of the Brazilian Chemical Society
سال: 2013
ISSN: 0103-5053
DOI: 10.5935/0103-5053.20130274